Stereoselective direct copper-catalyzed alkenylation of oxazoles with bromoalkenes |
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| Authors: | Besselièvre François Piguel Sandrine Mahuteau-Betzer Florence Grierson David S |
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| Affiliation: | Univ Paris-Sud, Orsay F-91405, France. |
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| Abstract: | A copper-catalyzed direct alkenylation of oxazoles with bromoalkenes has been developed. The method is both regio- and stereoselective and tolerates a variety of functional groups. A wide range of 2-E-vinyl-substituted oxazoles were obtained in high yields including the highly fluorescent alkaloid annuloline. |
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