| 2-氨基-4,6-二芳基吡啶的微波辐射促进合成 |
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| 引用本文： | 吴萍,蔡习美,颜朝国.2-氨基-4,6-二芳基吡啶的微波辐射促进合成[J].有机化学,2006,26(12):1673-1676. |
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| 作者姓名： | 吴萍 蔡习美 颜朝国 |
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| 作者单位： | 1. 扬州职业大学,扬州,225009
2. 扬州大学化学化工学院,扬州,225002 |
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| 基金项目： | 江苏省自然科学研究指导性计划(No.04KJD150237)项目，扬州市科技计划(No.YZ2004Z021)资助项目. |
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| 摘 要： | 氯化N-氰甲基吡啶在微波辐射下于醋酸铵/醋酸体系中和4种查尔酮反应, 或直接与芳香醛和取代苯乙酮一锅煮反应, 高产率地生成了2-氨基-4,6-二芳基吡啶衍生物. 化合物的结构经过IR, 1H NMR和HPLC-MS的表征.
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| 关 键 词： | 微波辐射 胺叶立德 查尔酮 吡啶盐 氨基吡啶 |
| 收稿时间： | 2005-12-13 |
| 修稿时间： | 2005年12月13 |
Microwave Irradiation Induced Synthesis of 2-Amino-4,6-diarylpyridines |
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| WU Ping,CAI Xi-Mei,YAN Chao-Guo.Microwave Irradiation Induced Synthesis of 2-Amino-4,6-diarylpyridines[J].Chinese Journal of Organic Chemistry,2006,26(12):1673-1676. |
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| Authors: | WU Ping CAI Xi-Mei YAN Chao-Guo |
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| Institution: | ( Yangzhou Polytechnic College, Yangzhou 225009)( College of Chem-istry & Chemical Engineering, Yangzhou University, Yangzhou 225002) |
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| Abstract: | Under microwave irradiation, N-cyanomethylpyridinium chloride (1) reacted with chalcone (2) in the presence of ammonium acetate and acetic acid to give 2-amino-4,6-diarylpyridines (5a～5c) in high yields. Compounds 5a～5i can also be prepared from one-pot reactions of 1 with aromatic aldehydes (3) and substituted acetophenones (4). The structures of the products were characterized with 1H NMR, IR and HPLC-MS spectra. |
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| Keywords: | microwave irradiation ammonium ylide chalcone condensation aminopyridine |
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