Synthesis and metal-binding properties of chelating fluorescein derivatives |
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| Authors: | Clark Matthew A Duffy Kathryn Tibrewala Jyoti Lippard Stephen J |
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| Institution: | Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. |
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| Abstract: | reaction: see text] Two routes to highly functionalized metal-chelating fluorescein derivatives have been pursued. Compound 3 is partially quenched by a variety of first-row transition metal ions in aqueous solution, with EC(50) values ranging from 0.4 to 60 microM. Compounds of this type may find application in biological sensing. |
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