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Antifungal and cytotoxic substances from the stem barks of Desmos chinensis |
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| Authors: | Monchanok Tuntipaleepuna Suda Chakthonga b Chanita Ponglimanonta Patimaporn Plodpaib c Supayang P.Voravuthikunchaib c a |
| Affiliation: | Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand ; Natural Products Research Center, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand ; Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand |
| Abstract: | Isounonal-7-methyl ether（1） and chinendihydrochalcone（2） together with 8 known compounds were isolated from the stem barks of Desmos chinensis.Their structures were determined on the basis of spectroscopic data.Compound 2 exhibited cytotoxic activity against MOLT-3 cancer cell line(IC50 7.16μg/mL) and antifungal activity against Pyricularia oryzae and Rhizoctonia solani with MIC values of 15.6 and 31.2μg/mL,respectively. |
| Keywords: | Dihydrochalcone Desmos chinensis Cytotoxic activity Antifungal activity |
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