四氮大环-金属配合物与DNA作用的电化学及谱学研究

Mononuclear copper（Ⅱ）, nickel（Ⅱ） and cobalt（Ⅲ） tetracoordinate macrocyclic complexes were synthesized and spectroscopically characterized. The crystal structure of the three compounds were determined by X-ray crystallography. The electrochemical experimental results indicate that the three complexes could interact with DNA mainly by electrostatic interaction. The interaction of tetracoordinate macrocyclic cobalt（Ⅲ） complex with DNA was studied by cyclic voltammetry and UV-vis spectroscopy. The experimental results reveal that tetracoordinate macrocyc- lic cobalt（Ⅲ） complex could interact with DNA by electrostatic interaction to form a 1 ： 1 DNA association complex with a binding constant of 7.50 ×10^3 L·mol^-1.

Electrochemical and Spectroscopic Studies on the Interaction between Tetracoordinate Macrocyclic Copper(II), Nickel(II) and Cobalt(III) Complexes with DNA

Mononuclear copper(II), nickel(II) and cobalt(III) tetracoordinate macrocyclic complexes were synthesized and spectroscopically characterized. The crystal structure of the three compounds were determined by X‐ray crystallography. The electrochemical experimental results indicate that the three complexes could interact with DNA mainly by electrostatic interaction. The interaction of tetracoordinate macrocyclic cobalt(III) complex with DNA was studied by cyclic voltammetry and UV‐vis spectroscopy. The experimental results reveal that tetracoordinate macrocyclic cobalt(III) complex could interact with DNA by electrostatic interaction to form a 1:1 DNA association complex with a binding constant of 7.50×10³ L·mol^?1.