Adsorption of cholic acid on surface of organosilicas containing chemically bound quaternary ammonium groups

It was found that silica modified with quaternary ammonium groups exhibits higher adsorption properties than cholesteramine, a sequestering adsorbent used in medicine for regulating the level of cholic acids in the organism. The constants of ion-exchange, aggregation, and stability, as well as the distribution coefficients, for synthesized organosilicas were calculated. It was shown that adsorption of cholic acid depends on the structure of the quaternary ammonium groups grafted to the silica surface.