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How Taxol stabilises microtubule structure |
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| Authors: | Amos L A Löwe J |
| Institution: | MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. laa@mrc-lmb.cam.ac.uk |
| Abstract: | The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer. |
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