| 刺老苞根皮干预大鼠骨折模型矿物元素含量变化 |
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| 引用本文： | 尹霞,郑玲玲,白岩,裴凌鹏. 刺老苞根皮干预大鼠骨折模型矿物元素含量变化[J]. 广东微量元素科学, 2011, 18(6): 23-27 |
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| 作者姓名： | 尹霞 郑玲玲 白岩 裴凌鹏 |
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| 作者单位： | 尹霞,YIN Xia(中国中医科学院望京医院骨伤科研究所,北京,100070);郑玲玲,白岩,裴凌鹏,ZHENG Lingling,BAI Yan,PEI Lingpeng(中央民族大学中国少数民族传统医学国家民委 - 教育部重点实验室,北京,100081) |
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| 基金项目： | 国家自然科学基金，教育部"长江学者和创新团队发展计划"资助 |
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| 摘 要： | 为探讨土家族药刺老苞根皮对大鼠骨折模型胫骨矿物元素的影响,将250只SD大鼠(雌雄各半)随机分成对照组、模型组和刺老苞根皮黄酮高、中、低(30、20、10 mg·kg-1)剂量组,每组10只,分别灌胃相应药物,每日1次,连续4周,用电感耦合等离子体质谱法(ICP - MS)测定了给药第4天、第7天、第14天、第21天和...
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| 关 键 词： | 刺老苞根皮 黄酮 微量元素 骨折愈合 |
Study on effect of Aralia echinocaulis Hand.Mazz in Rat Fracture Model |
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| YIN Xia,ZHENG Lingling,BAI Yan,PEI Lingpeng. Study on effect of Aralia echinocaulis Hand.Mazz in Rat Fracture Model[J]. Trace Elements Science, 2011, 18(6): 23-27 |
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| Authors: | YIN Xia ZHENG Lingling BAI Yan PEI Lingpeng |
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| Affiliation: | YIN Xia1,ZHENG Lingling2,BAI Yan2,PEI Lingpeng2(1.China Academy of Chinese Medical Sciences,Wangjing Hospital,Institute of Orthopaedics and Traumatology,Beijing 100070,China,2.State Nationalities Affairs Commission and Development of Educational Key Lab of Chinese Minority Traditional Medicine,Minzu University of China,Beijing 100081,China) |
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| Abstract: | To investigate the effect of Aralia echinocaulis Hand.Mazz on bone mineral elements of fracture model in SD rat,250 SD rats were randomly divided into control group,model group,Aralia echinocauIis Hand.Mazz flavonoids low dosage group(10 mg·kg-1),middle dosage group(20 mg·kg-1)and high dosage group(30 mg·kg-1).Rats in the control group were treated with dissolvent,the others were treated with fractured firstly,and then,the rats in model group were treated with dissolvent,the Aralia echinocauIis Hand.Mazz different groups were treated with related dosage flavonoids,respectively,once a day.During 4 weeks,target metal elements(Ca,Mg,P,Mn,Cu,Se,Zn)of tibia in different times(including the 4 th day,the 7 th day,the 14th day,the 21 st day and the 28 th day)were analyzed by ICP-MS.The results showed that Aralia echinocaulis Hand.Mazz flavonoids could improve the content of seven metal elements in tibia fracture model.It provided useful data for discussing the relationship between the content of the metal elements in Aralia echinocaulis Hand.Mazz and mechanism of fracture healing. |
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| Keywords: | Aralia echinocaulis Hand.mazz flavonoids metal elements fracture healing |
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