In Vivo3D LocalizedC Spectroscopy Using Modified INEPT and DEPT |
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Authors: | H Watanabe Y Ishihara K Okamoto K Oshio T Kanamatsu Y Tsukada |
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Institution: | aToshiba Research and Development Center, Kawasaki, 210-8582, Japan;bInstitute of Life Science, Soka University, Hachioji, 192-8577, Japan |
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Abstract: | The 3D localized13C spectroscopy methods LINEPT and LODEPT, which are modifications of INEPT and DEPT, are proposed. As long as a13C inversion pulse (180-degree pulse) is applied at 1/(4J) before the proton echo time in LINEPT and a13C excitation pulse (90-degree pulse) is applied at 1/(2J) before the proton echo time in LODEPT, the proton echo time can be set to any value longer than 1/(2J) in LINEPT and longer than 1/Jin LODEPT. As a result, the proton and the13C pulses can be applied separately and these proton pulses can be made slice-selective pulses. These localization features of LINEPT and LODEPT were evaluated using a phantom consisting of a cylinder filled with ethanol placed inside another cylinder filled with oil, and localized ethanol spectra could be obtained.In vivo3D localized13C spectra from the brain of a monkey could be obtained using decoupled LINEPT, and glutamate C-4 appeared directly after the administration of glucose C-1, followed by the appearance of glutamate C-2, C-3 and glutamine C-2, C-3, C-4. |
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Keywords: | 13C-MRS in vivo localization INEPT DEPT |
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