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A stereoselective route to multi-substituted tetrahydropyrans by vinyl radical cyclization |
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| Authors: | Naoki Hiramatsu Ryoji Noyori Yuji Mori |
| Affiliation: | a Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya 468-8503, Japan b Department of Chemistry and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8606, Japan |
| Abstract: | The tin-mediated 6-exo-trig radical cyclization of the acetylenic β-alkoxy acrylates proceeded smoothly to give fully substituted tetrahydropyrans in good yields with high equatorial selectivity irrespective of the stereochemistry of the propargylic position. |
| Keywords: | Radical cyclization Tetrahydropyrans Polycyclic ethers Alkoxy acrylates |
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