Synthesis of functionalized m-bistrifluoromethylbenzenes via cyclocondensation of 1,1,1,5,5,5-hexafluoroacetylacetone with enamines |
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| Authors: | Dmitriy M Volochnyuk Dmitriy A Sibgatulin Alexander N Chernega |
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| Institution: | Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanskaya 5, 02094 Kyiv-94, Ukraine |
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| Abstract: | The reaction of 1,1,1,5,5,5-hexafluoroacetylacetone with push-pull enamines having a methyl group at the α-position was investigated. It was found that the reaction is sensitive both to the structure of enamines and to reaction conditions. As a result, a set of bistrifluoromethyldialkylanilines and ethyl bistrifluoromethylsalicylate was prepared. Plausible mechanisms and factors influencing the course of the reaction are discussed. |
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| Keywords: | 1 1 1 5 5 5-Hexafluoroacetylacetone Push-pull enamines Trifluoromethylated benzenes Cyclocondensation |
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