Intermolecular reductive coupling of hindered N-aryl imines towards the modular synthesis of chiral N-heterocyclic carbenes |
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| Authors: | Gregory J Mercer |
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| Institution: | Department of Chemistry, University of Utah, 315 S. 1400 East Salt Lake City, UT 84112, USA |
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| Abstract: | We describe a simple method for the synthesis of hindered N-aryl diamines. The diastereoselectivity for these processes are relatively low but the diamines can be separated using either chromatography or selective crystallization. Separation of enantiomers can be accomplished using HPLC equipped with a chiral stationary phase. |
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| Keywords: | N-Aryl Cross coupling Reductive coupling |
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