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Aza-Wittig reaction of fluoroalkylated N-vinylic phosphazenes with carbonyl compounds. Usefulness of 2-azadienes for the preparation of fluoroalkyl pyridine derivatives |
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| Authors: | Francisco Palacios Concepción Alonso Gloria Rubiales Maite Villegas |
| Institution: | Departamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco, Apartado 450, 01080, Spain |
| Abstract: | A method for the preparation of 3-fluoroalkyl substituted 2-aza-butadienes 6 by aza-Wittig reaction of 3-fluoroalkyl-N-vinylic phosphazenes 4 and aldehydes 5 is reported. 4+2] Cycloaddition reaction of these heterodienes 6 with enamines 9 gives fluoroalkyl substituted pyridine 15, 16, 24-27 and isoquinoline 12-14, 20 derivatives. |
| Keywords: | N-vinylic phosphazenes Aza-Wittig reaction 2-Aza-1 3-butadienes Fluoroalkyl derivatives Heterocycles |
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