Synthesis of fused indoles by sequential palladium-catalyzed Heck reaction and N-heteroannulation |
| |
Authors: | Björn CG Söderberg Jeremiah W Hubbard Stacey R Rector Shannon N O'Neil |
| |
Institution: | C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV 26506-6045, USA |
| |
Abstract: | A route to 3,4-fused indoles via two consecutive palladium-catalyzed reactions; an intramolecular Heck reaction followed by a reductive N-heteroannulation is described. Using this route, a number of indoles have been prepared having a variety of ring sizes anchored to the 3- and 4-position of the indole nucleus. Furthermore, a number of functional groups, both carbon and heteroatom substituents can be introduced in (and on) the additional ring without any detrimental effects on the two reactions. |
| |
Keywords: | Palladium-catalyzed Indoles Reductive Annulation |
本文献已被 ScienceDirect 等数据库收录! |