Synthesis of novel cyclodextrin derivatives by aromatic spacer insertion and their inclusion ability |
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Authors: | Toshiyuki Kida |
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Affiliation: | Department of Molecular Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan |
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Abstract: | Novel cyclic host molecules were synthesized by the insertion of three types of aromatic spacers into the skeleton of permethylated α-cyclodextrin. These host molecules formed a 1:1 complex with sodium 3- and 4-nitrobenzenesulfonates (3- and 4-NBS), and sodium 2,4-dinitrobenzenesulfonate (DNBS) in D2O/CD3OD (4:1) solution. The type of spacer inserted remarkably affected the inclusion ability of the hosts toward DNBS. The p-xylylene-inserted CDs showed greater inclusion ability toward DNBS than permethylated α- and β-CDs. |
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Keywords: | Host molecule Cyclodextrin Spacer insertion Inclusion ability |
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