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New antiproliferative 14,15-secopregnane glycosides from Solenostemma argel |
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| Authors: | Alberto Plaza Ciro Balestrieri Giuseppe Bifulco Arafa Hamed Sonia Piacente |
| Institution: | a Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, via Ponte Don Melillo, 84084 Fisciano (SA), Italy b Dipartimento di Biochimica e Biofisica, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy c Centro di Spettrometria di Massa Proteomica e Biomolecolare, Istituto di Scienze dell'alimentazione-C.N.R., Via Roma 52a-c, 83100 Avellino, Italy d Faculty of Science, South Valley University, 81528 Aswan, Egypt |
| Abstract: | Eight new 14,15-secopregnane glycosides, namely argelosides C-J, possessing two ketal functions involved in three five-membered rings, have been isolated from the hairy seeds of Solenostemma argel. Their structures have been established by MS and NMR experiments, combined with quantum mechanical calculations of the 13C chemical shifts for the interpretation of the experimental data. On the basis of the obtained results, the structures of argelosides A and B have been revised. Additionally, the effect of these compounds on the VEGF-induced in Kaposi's sarcoma cell proliferation was evaluated. Results indicated that all the compounds reduced the cell proliferation in a dose-dependent manner. |
| Keywords: | Solenostemma argel 14 15-Secopregnane GIAO NMR DFT calculations Cell proliferation Kaposi's sarcoma |
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