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Synthesis of (Z)-1-bromo-1-alkenes and terminal alkynes from anti-2,3-dibromoalkanoic acids by microwave-induced reaction |
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| Authors: | Chunxiang Kuang Qing Yang Masao Tokuda |
| Institution: | a Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Suita 565-0871, Japan b Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan c Division of Molecular Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan |
| Abstract: | (Z)-1-Bromo-1-alkenes were stereoselectively prepared in high yields in a short reaction time by microwave irradiation of the corresponding anti-2,3-dibromoalkanoic acids in a Et3N/DMF system. A one-pot synthesis of terminal alkynes and enynes from 2,3-dibromoalkanoic acids were also developed by microwave-induced reaction. |
| Keywords: | (Z)-1-Bromo-1-alkenes anti-2 3-Dibromoalkanoic acids Terminal alkynes Enynes Microwave irradiation |
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