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[1,2] Boc migration during pyroglutamate alkylations |
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| Authors: | Nicolai Dieltiens Kurt G.R. Masschelein Thomas Rammeloo |
| Affiliation: | Research group SynBioC, Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Ghent, Belgium |
| Abstract: | Treatment of N-Boc protected pyroglutamates with strong bases lead to a Boc migration from the N-atom to the C2 position when no or poor electrophiles are being used. |
| Keywords: | Boc migration Pyroglutamate Alkylation Carbamates |
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