An iodoacetamide-based free radical cyclisation approach to the 7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one (paullone) system |
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| Authors: | John B. Bremner Waya Sengpracha |
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| Affiliation: | Institute for Biomolecular Science and Department of Chemistry, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia |
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| Abstract: | A potentially versatile route to 2-(2-aminoaryl)indoles is described based on a palladium-mediated cyclisation of N-substituted indoles, together with free radical cyclisation of their N-benzyliodoacetamide derivatives to the 7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one system. |
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| Keywords: | Indolobenzazepinones Iodoacetamides Radical cyclisation 7-Membered ring |
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