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Janoxepin and brevicompanine B: antiplasmodial metabolites from the fungus Aspergillus janus |
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| Authors: | Kennett Sprogøe Søren Manniche Carsten Christophersen |
| Institution: | a Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark b Mycology Group, Department of Biotechnology and Department of Organic Chemistry, Technical University of Denmark, DK-2800 Lyngby, Denmark c Marine Chemistry Section, Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark |
| Abstract: | Two compounds janoxepin (1) and brevicompanine B (2) were isolated from the fungus Aspergillus janus and the structures elucidated by one- and two-dimensional NMR spectroscopic methods and mass spectrometry. Janoxepin is a novel oxepin derivative with a rare d-leucine incorporated. Brevicompanine B has previously only been isolated from Penicillium brevicompactum. Both compounds were tested in antimicrobial assays and found to be active against the malaria parasite Plasmodium falciparum 3D7 (IC50-values of 28 and 35 mg/ml, respectively). However, no activity was observed in antifungal or antibacterial assays. |
| Keywords: | UV-guided screening NMR Janoxepin Brevicompanine B Antiplasmodial Fungal metabolites |
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