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Solvent-free condensation of arylacetonitrile with aldehydes |
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| Authors: | Ré gis Guillot,Abdelkrim Meddour,Alain Petit |
| Affiliation: | a Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Sud, bâtiment 420, 91405 Orsay cedex, France b Laboratoire des Réactions Sélectives sur Supports, CNRS UMR 8615, Université Paris-Sud, bâtiment 410, 91405 Orsay cedex, France c Laboratoire ‘ RMN en milieu orienté ’, CNRS 8074, Université Paris-Sud, bâtiment 410, 91405 Orsay cedex, France d Laboratoire des Carbocycles, CNRS UMR 8615, Université Paris-Sud, bâtiment 420, 91405 Orsay cedex, France |
| Abstract: | The condensation of a series of arylacetonitriles with aldehydes can be carried out by mixing equivalent amounts of reagents with neat powdered KOH at room temperature for 3-60 min depending on the aldehyde steric hindrance. At higher temperature (110 °C), yields were generally higher and purity increased within very short reaction times (1-5 min). With pentamethylphenylacetonitrile, a phase transfer agent was necessary to give a satisfactory yield. |
| Keywords: | Solvent-free condensation Microwave irradiation Phase transfer catalysis X-ray crystallography |
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