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Structure and absolute stereochemistry of novel C15-halogenated acetogenins from the anaspidean mollusc Aplysia dactylomela |
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| Authors: | Emiliano Manzo M. Letizia Ciavatta Raffaella Puliti Yue-Wei Guo Guido Cimino |
| Affiliation: | a Istituto di Chimica Biomolecolare, CNR, Via Campi Flegrei 34, I 80078 Pozzuoli (Na), Italy b State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences, 201203, Shanghai, China c Dipartimento di Scienze Farmaceutiche, Universita' di Salerno, via Ponte Don Melillo, I-84084 Fisciano, Salerno, Italy d Dipartimento di Chimica, Università “Federico II”, Complesso Universitario di Monte S. Angelo, via Cintia, I-80126 Napoli, Italy |
| Abstract: | Three novel halogenated C15-acetogenins, compounds 1-3, have been isolated, together with known metabolites, from a South China Sea collection of the anaspidean mollusc Aplysia dactylomela. The structures have been suggested by both NMR analysis and comparison with literature data. The structure of 1 was confirmed by a single crystal X-ray study, which also allowed the establishment of its absolute stereochemistry. |
| Keywords: | Marine natural products Molluscs Acetogenins Absolute stereochemistry |
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