Synthesis of pyrrolo[3,4-c]quinolines by 1,5-electrocyclisation of non-stabilised azomethine ylides |
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| Authors: | Mikló s Nyerges,Á ron Pinté r,Gá bor Blaskó |
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| Affiliation: | a Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, H-1521 Budapest PO Box 91, Hungary
b EGIS Pharmaceuticals Ltd, H-1475 Budapest PO Box 100, Hungary |
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| Abstract: | A new route to the pyrrolo[3,4-c]quinoline ring system has been developed via the 1,5-dipolar electrocyclisation reactions of azomethine ylides derived from easily available 3-formylquinoline derivatives. The intermediacy of azomethine ylides was shown by the trapping of the proposed dipoles with N-phenylmaleimide. |
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| Keywords: | Azomethine ylide Cycloaddition Electrocyclisation Pyrroles |
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