One-pot enzymatic desymmetrization and Ugi MCR |
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| Authors: | Anna Fryszkowska Ryszard Ostaszewski |
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| Institution: | a Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
b Institute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland |
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| Abstract: | A new approach to the synthesis of chiral peptidomimetics is reported. It combines an enzymatic desymmetrization of 3-phenylglutaric anhydrides with a subsequent Ugi multi-component reaction in a one-pot, two-step procedure. NMR and CD spectroscopy was used to assign the configurations of obtained products. Our synthetic method is very efficient and it can easily be extended to other types of multi-component reactions and can be used for the preparation of chiral peptidomimetic libraries. |
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| Keywords: | Enzyme Desymmetrization Peptidomimetic |
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