4-Substituted prolines as organocatalysts for aldol reactions |
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| Authors: | Evagelos Bellis |
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| Affiliation: | Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece |
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| Abstract: | A series of 4-substituted prolines were prepared and evaluated as organocatalysts for asymmetric aldol reactions. Using (2S,4R)-4-camphorsulfonyloxy-proline, the aldol products were obtained in much higher enantiomeric excess in comparison to that observed using proline itself. In addition, the improved solubility of these new catalysts in organic solvents permits their use in lower sub-stoichiometric amounts compared to proline. |
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| Keywords: | Aldol reactions Amino acids Asymmetric catalysis Organocatalysts 4-Substituted proline |
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