Enantioselective synthesis of β-amino alcohols and α-amino acids via a copper catalyzed addition of diorganozinc reagents to N-phosphinoylimines |
| |
Authors: | Jean-Nicolas Desrosiers |
| |
Institution: | Département de Chimie, Université de Montréal, PO Box 6128, Station Downtown, Montreal, Que., Canada H3C 3J7 |
| |
Abstract: | Enantioenriched β-amino alcohols were prepared via an asymmetric addition of diethylzinc, catalyzed by the BozPHOS·Cu(I) complex, on in situ formed N-phosphinoylimines. The nature of the hydroxyl protecting groups was found to affect the enantioselectivities. Subsequent deprotection and oxidation of N-phosphinoyl β-amino alcohols afforded optically active α-amino acids (97% ee). |
| |
Keywords: | β-Amino alcohols α-Amino acids Enantioselective synthesis Imines Copper Diorganozinc reagents |
本文献已被 ScienceDirect 等数据库收录! |
|