Synthesis of the phthalide-containing anti-Helicobacter pylori agents CJ-13,015, CJ-13,102, CJ-13,103, CJ-13,104 and CJ-13,108 |
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| Authors: | Margaret A Brimble Christopher L Flowers James K Hutchinson James E Robinson Matthew Sidford |
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| Institution: | Department of Chemistry, University of Auckland, 23 Symonds Street, Auckland 1000, New Zealand |
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| Abstract: | Flexible racemic syntheses of the phthalide-containing antibiotics CJ-13,015, CJ-13,102, CJ-13,103, CJ-13,104 and CJ-13,108 that inhibit Helicobacter pylori have been carried out in a convergent fashion by Wittig coupling of a phthalide-containing aldehyde fragment with an appropriate phosphorous ylide. |
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| Keywords: | Phthalides Helicobacter pylori Wittig reaction |
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