A bis(η-cyclopentadienyl)cobalt complex of a bis-dithiolene: a chemical analogue of the metal centres of the DMSO reductase family of molybdenum and tungsten enzymes, in particular ferredoxin aldehyde oxidoreductase |
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| Authors: | France-Aimé e Alphonse,Cé line Cano-Soumillac,David Collison,John A. Joule |
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| Affiliation: | a The School of Chemistry, The University of Manchester, Manchester M13 9PL, UK
b School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK |
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| Abstract: | The synthesis is described of a bis-ene-1,2-dithiolate pro-ligand, designed to model the stereochemical situation in the cofactor of the tungsten enzyme ferredoxin aldehyde oxidoreductase from Pyrococcus furiosus. Each masked ene-1,2-dithiolate unit is mounted on a pyrano[2,3-b]tetrahydroquinoxaline tricycle, comparable to the pyrano[2,3-g]tetrahydropteridines found in all molybdoenzymes and tungsten analogues. Hydrolytic release of the bis-ligand was confirmed by its entrapment as a double (η5-C5H5)Co complex. |
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| Keywords: | Aldehyde Tungsten Ligand DMSO reductase family Pyrano[2,3-b]quinoxaline Enedithiolate |
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