Biotransformation of 7-oxo-ent-kaur-16-ene derivatives by Gibberella fujikuroi |
| |
Authors: | Braulio M Fraga Pedro González Sergio Suárez |
| |
Institution: | a Instituto de Productos Naturales y Agrobiología, CSIC, Avda. Astrofísico F. Sánchez 3, 38206-La Laguna, Tenerife, Canary Islands, Spain b Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna, Tenerife, Spain |
| |
Abstract: | The microbiological transformation of 7-oxo-ent-kaur-16-ene by the fungus Gibberella fujikuroi gave fujenoic acid as the main compound, whilst the incubation of 18-hydroxy-7-oxo-ent-kaur-16-ene and 3α,18-dihydroxy-7-oxo-ent-kaur-16-ene afforded the corresponding 6β-hydroxy-derivatives. These facts indicate that the formation of fujenoic acid in this biotransformation should occur via a 7-oxo-6β-hydroxy derivative. In the three biotransformations, an 11β-hydroxylation was also produced, in low yield, indicating that a 7-oxo-group also directs hydroxylation at C-11. |
| |
Keywords: | Gibberella fujikuroi Microbiological transformations Diterpenes 7-Oxo-ent-kaur-16-ene derivatives |
本文献已被 ScienceDirect 等数据库收录! |
|