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Tri-component reaction of 2-alkyl-4,5-dichloropyridazin-3(2H)-ones: synthesis of 5-cyano-5-(pyrimidin-2-yl)-2,7-dialkyl-5H-dipyridazino-[4,5-b:4,5-e]-4H-thiopyran-1,6-dione and 2-(4-cyanophenoxy) pyrimidine |
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| Authors: | Jung-Won Park Ho-Kyun Kim Su-Dong Cho Yong-Jin Yoon |
| Affiliation: | a Department of Chemistry and Environmental Biotechnology, National Core Research Center, Gyeongsang National University, Chinju 660-701, South Korea b Department of Chemistry, Research Institute of Basic Sciences, Changwon National University, Changwon 641-773, South Korea c Rikagu Corporation, 3-9-12 Matsubara-cho, Akishima-shi, Tokyo 196-8666, Japan |
| Abstract: | Reaction of 2-alkyl-4,5-dichloropyridazin-3(2H)-ones with p-cyanophenol and 2-mercaptopyrimidine in the presence of base gave 2,4,5-trisubstituted-pyridazin-3(2H)-ones 4-9, 2-(4-cyanophenoxy)pyrimidine (10) and 5-cyano-5-(pyrimidin-2-yl)-2,7-dialkyl-5H-dipyridazino[4,5-b:4,5-e]-4H-thiopyran-1,6-diones 11 as a novel heterocycle. |
| Keywords: | Tri-component reaction 2-Alkyl-4,5-dichloropyridazin-3(2H)-ones 5-Cyano-5-(pyrimidin-2-yl)-2,7-dialkyl-5H-dipyridazino[4,5-b:4,5-e]-4H-thiopyran-1,6-diones 2-(4-Cyanophenoxy)pyrimidine |
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