A facile synthesis of highly functionalized dihydrofurans based on 1,4-diazabicyclo[2.2.2]octane (DABCO) catalyzed reaction of halides with enones |
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| Authors: | Zhanjun Yang Ruizhu Mu Yongmin Liang |
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| Affiliation: | a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China
b Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, People's Republic of China |
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| Abstract: | Treatment of halides 5 with electrophilic alkenes 2 afforded the corresponding dihydrofurans 3 and 4 in the presence of 1, 4-diazabicyclo[2.2.2]octane (DABCO) with good to excellent yields and in a stereoselective manner in most cases. Moreover, the stereoisomers 3 and 4 could be easily transformed each other in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). |
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| Keywords: | DABCO Ylides Enones Dihydrofurans Furans |
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