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An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect |
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| Authors: | Nadya Kaval,Giang Vo-Thanh,Johan Van der Eycken,André Loupy |
| Affiliation: | a Department of Chemistry, Catholic University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium b Department of Organic Chemistry, Semmelweis University, H?gyes u. 7, Budapest, Hungary c Laboratoire des Réactions Sélectives sur Supports, CNRS UMR 8615, Université Paris-Sud, ICMMO, bâtiment 410, 91405 Orsay Cedex, France d Laboratory for Organic and Bio-organic Synthesis, Gent University, Krijgslaan 281, B-9000 Gent, Belgium |
| Abstract: | Significant improvements in the synthesis of pyrido-fused heterocycles were observed when performing the reaction under solvent-free conditions, applying the tert-amino effect as the key ring closure methodology. An unexpected cyclization of ortho-(1′-azacycloalkyl)benzaldehydes has been studied in water and on solid support. |
| Keywords: | Microwave tert-Amino effect Pyrido-fused Solvent free |
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