Synthesis of (±)-5′-methoxyhydnocarpin-D, an inhibitor of the Staphylococcus aureus multidrug resistance pump |
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| Authors: | Kin-Fai Chan |
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| Institution: | Department of Applied Biology and Chemical Technology and the Open Laboratory for Chiral Technology, the Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, The State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Schenzhen, China |
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| Abstract: | The total synthesis of regioisomerically pure (±)-5′-methoxyhydnocarpin-D (6) from commercially available vanillin (7), methyl gallate (9) and 2′,4′,6′-trihydroxyaceophenone (10) is achieved. |
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| Keywords: | Staphylococcus aureus Multidrug resistance NorA 5&prime -Methoxyhydnocarpin-D Mitsunobu reaction |
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