Synthesis of chlorinated 2-(aminomethyl)- and 2-(alkoxymethyl)pyrroles |
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| Authors: | Guido Verniest |
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| Institution: | Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium |
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| Abstract: | The synthesis of chlorinated 2-(hydroxymethyl)-, 2-(alkoxymethyl)- and 2-(aminomethyl)pyrroles via aromatization of 2-aryl-3,3-dichloro-5-(bromomethyl)pyrrolines and via reduction of 2-formyl- and 2-cyanopyrroles is described. The former methodology also provided new 2-(alkyl- or phenylamino)methyl]pyrroles and a 2-(phosphonomethyl)pyrrole. Halogenated and methylene-spaced functionalized pyrroles are of particular interest for their pronounced physiological activities. |
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| Keywords: | Pyrroles Trichloroisocyanuric acid Pyrrolines |
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