Efficient palladium catalysts for the amination of aryl chlorides: a comparative study on the use of phosphium salts as precursors to bulky, electron-rich phosphines |
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| Authors: | Amit Tewari Alexander Zapf |
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| Institution: | a Institut für Chemie, Universität Rostock, Albert-Einstein-Straße 3a, D-18059 Rostock, Germany
b Leibniz-Institut für Organische Katalyse an der Universität Rostock e.V. (IfOK), Albert-Einstein-Str. 29a, D-18059 Rostock, Germany |
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| Abstract: | Alkyl-di-(1-adamantyl)phosphonium salts are practical ligand precursors for the palladium-catalyzed amination of aryl chlorides. In the presence of typically 0.5 mol% Pd(OAc)2 and 1 mol% of ligand precursor a variety of activated and deactivated aryl chlorides can be aminated in good to excellent yield (73-99%). Applying optimized conditions catalyst turnover numbers up to 10,000 have been achieved. |
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| Keywords: | Amination Anilines Aryl chlorides Palladium Phosphines |
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