A new one-pot synthesis of α-Gal epitope derivatives involved in the hyperacute rejection response in xenotransplantation |
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| Authors: | Yuhang Wang |
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| Affiliation: | The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd #38, Beijing 100083, China |
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| Abstract: | Xenotransplantations from pig to human are rapidly rejected because of the interaction between α-Gal epitopes carried by the graft and natural antibodies (anti-Gal antibodies) present in the blood of the recipient. This paper describes a three-component one-pot synthesis of three α-Gal related oligosaccharides with minimal protecting group manipulations in a very short period of time. |
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| Keywords: | α-Galactosyl epitopes One-pot synthesis Glycosylations Oligosaccharides Xenotransplantation |
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