Regioselective enzymatic acylation of vicinal diols of steroids |
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| Authors: | M Manuel Cruz Silva M Luisa Sá e Melo |
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| Institution: | a Centro de Estudos Farmacêuticos, Lab. Química Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra, Rua do Norte 3000-295 Coimbra, Portugal
b Istituto di Chimica del Riconoscimento Molecolare, C.N.R., Via Mario Bianco 9, 20131 Milano, Italy |
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| Abstract: | Monoacylated derivatives of a complete set of 2,3- and 3,4-vicinal diols of steroids were prepared by regioselective lipase-catalysed transesterification reactions. The enzymes displayed different selectivities towards the vicinal diols depending on the configuration of the hydroxyl groups. |
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| Keywords: | Lipases Steroids Diols Regioselectivity Enzymatic esterification |
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