An efficient Stille cross-coupling reaction catalyzed by Pd(OAc)2/DAB-Cy catalytic system |
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| Authors: | Jin-Heng Li Yun Liang Ye-Xiang Xie |
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| Affiliation: | Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China |
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| Abstract: | An efficient palladium-catalyzed Stille cross-coupling reaction has been developed. In the presence of 3 mol% of Pd(dba)2 and 6 mol% of DAB-Cy (1,4-dicyclohexyl-diazabutadiene), various aryl halides (iodides and bromides) were coupled with organotin compounds to afford the corresponding biaryls and alkyne in good to excellent yields. Furthermore, high TONs [turnover numbers, TONs up to 950,000 for the reaction of 1-iodo-4-nitrobenzene and tributyl(phenyl)stannane] for the Stille cross-coupling reaction were observed. |
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| Keywords: | Pd(dba)2/DAB-Cy Stille cross-coupling reaction Aryl halide Organotin compound Turnover number |
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