An efficient Stille cross-coupling reaction catalyzed by Pd(OAc)2/DAB-Cy catalytic system |
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| Authors: | Jin-Heng Li Yun Liang Ye-Xiang Xie |
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| Institution: | Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China |
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| Abstract: | An efficient palladium-catalyzed Stille cross-coupling reaction has been developed. In the presence of 3 mol% of Pd(dba)2 and 6 mol% of DAB-Cy (1,4-dicyclohexyl-diazabutadiene), various aryl halides (iodides and bromides) were coupled with organotin compounds to afford the corresponding biaryls and alkyne in good to excellent yields. Furthermore, high TONs turnover numbers, TONs up to 950,000 for the reaction of 1-iodo-4-nitrobenzene and tributyl(phenyl)stannane] for the Stille cross-coupling reaction were observed. |
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| Keywords: | Pd(dba)2/DAB-Cy Stille cross-coupling reaction Aryl halide Organotin compound Turnover number |
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