Facile one-pot synthesis of BINOL- and H8-BINOL-based aryl phosphites and their use in palladium catalysed asymmetric allylation |
| |
| Authors: | Konstantin N. Gavrilov Pavel V. Petrovskii AntonS. Safronov Vadim A. Davankov |
| |
| Affiliation: | a Department of Chemistry, Ryazan State Pedagogic University, 46 Svoboda Street, Ryazan 390000, Russia
b Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Street, 119991 Moscow, Russia |
| |
| Abstract: | Novel P-monodentate aryl phosphite ligands have been synthesised in one step from (R)-BINOL, (R)-H8-BINOL and (R)-H8-3,3′-dibromo-BINOL. With the new aryl phosphites, up to 86% ee was observed in the asymmetric Pd-catalysed amination of 1,3-diphenyl-2-propenyl acetate with sodium diformylamide. In the enantioselective alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate, up to 97% enantioselectivity was achieved. |
| |
| Keywords: | P-monodentate phosphite ligands Asymmetric Pd-catalysed amination Enantioselective alkylation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
