DSC
examinations on cataractous lens materials obtained by phacoemulsification |
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| Authors: | Zs Biró Vanda Nemes G A Molnár I Wittmann Andrea Ludány D Lőrinczy |
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| Institution: | (1) Department of Ophthalmology, University of Pécs, Pécs, Hungary, 7624, Szigeti street 12;(2) 2nd Department of Medicine and Nephrological Center, University of Pécs, Pécs, Hungary, 7624, Szigeti street 12;(3) Department of Laboratory Medicine, University of Pécs, Pécs, Hungary, 7624, Szigeti street 12;(4) Department of Biophysics, Faculty of Medicine, University of Pécs, Pécs, Hungary, 7624, Szigeti street 12 |
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| Abstract: | Modifications
of lens proteins play a crucial role in the formation of cataract, which is
among the leading causes of world blindness in the ageing population. Although
modern cataract surgery by phacoemulsification is a very successful and safe
procedure, the prevention of cataract formation would be a real breakthrough
in this field of ophthalmology.
The aim of our study was to analyse
the thermal denaturation of the cataractous lens proteins by the method of
differential scanning calorimetry (DSC), to understand cataract formation
and to work on its prevention possibilities. Samples were obtained from cataract
patients of different age, sex, patients with and without diabetes mellitus.
Samples were obtained from lenses of mature degree and progredient degree
of cataract as well.
Previous DSC examinations were performed
on manually extracted human cataractous lens materials, however to the best
of our knowledge, this is the first study, in which DSC examinations were
performed on lens materials obtained by the phacoemulsification technique,
which gained acceptance world-wide in the last decade.
The online version of the original
article can be found
at |
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| Keywords: | cataract diabetes DSC phacoemulsification |
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