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Preparation and Application of two New Types of Oxazaborolidines |
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| 作者姓名： | Guo Bin RONG" target="_blank">Guo Bin RONG Xing Ming
LI Yong ZHANG |
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| 作者单位： | Department of Chemistry East China University of Science and Technology,Shanghai 200237
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| 基金项目： | This work was supported by, the NNSFC.!(29972012) |
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| 摘 要： | Stereoselectivereductionoftheprochiralketonesisoneofthemostactivelystudiedareasinasymmetricsynthesis.Inthiscontext,oxazaborolidinecatalysedreductionhasemergedasoneofthemostprominentmethodology'.(is,Zs)-2-amino-l-(4-nitrophenyl)-propane-l,3-diolIisaby-productinthechloramphenicolmanufacture.Inthispaped,wereporttheresultsofthecatalyticasy-mmetricreductionofacetophenoneswithboraneinthepresenceofchiralligandart-singfrom1.Thepreparationofligand2isscheduledand3canbeproducedfrom12.The10%mol.of2or3rea…
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The Preparation and Application of two New Types of Oxazaborolidines |
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| Guo Bin RONG,Xing Ming
LI,Yong ZHANG.The
Preparation and Application of two New Types of Oxazaborolidines[J].Chinese Chemical Letters,2000,41(5):381-382. |
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| Authors: | Guo Bin RONG Xing Ming LI Yong ZHANG |
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| Institution: | Department of Chemistry East China University of Science and Technology. Shanghai 200237 |
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| Abstract: | Two new type of 1.3.2-oxazaborolidines were prepared from (1s.2s)-2-amino-1-(4- nitrophenyl)-propane-1.3-diol and were used as catalyst in the asymmetric reduction of acetophenone. The influence of the reaction temperature as well as the effect of the structure of catalyst on the enantioselectivity was investigated. The origin of the products' contlguration was discussed. |
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| Keywords: | Oxazborolidine asymmetric catalytic reduction prochiral ketone |
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