A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres |
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| Authors: | Narumi Tetsuo Niida Ayumu Tomita Kenji Oishi Shinya Otaka Akira Ohno Hiroaki Fujii Nobutaka |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan. |
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| Abstract: | By a novel one-pot reaction sequence involving consecutive organocopper-mediated reduction, transmetalation and asymmetric alkylation, a highly diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres was achieved in good to excellent yields. |
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