Synthesis of isothiocoumarin derivatives |
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Authors: | N T Pokhodylo V S Matiychuk M D Obushak |
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Institution: | (1) Ivan Franko National University of Lviv, Lviv, 79005, Ukraine; |
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Abstract: | A method was developed for the synthesis of 1-oxo-1H-isothiochromenes from 2-benzofuran-1(3H)-one (phthalide). 3-Bromo-6-chloro-
and 3,6-dibromo-2-benzofuran-1(3H)-ones were prepared by the bromination of 6-chloro- and 6-bromo-2-benzofuran-1(3H)-ones
and were converted by hydrolysis into 5-chloro- or 5-bromo-2-formylbenzoic acids. The condensation of these acids with rhodanine
followed by recyclization gave 7-chloro- and 7-bromo-1-oxo-1H-isothiochromene-3-carboxylic acids. |
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