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| 99mTcN核标记的新型心肌灌注显像剂的研究 | |
| 引用本文： | 楚进锋,孔德靖,李彬,王学斌,陆洁,王金城,米宏志,赵建冬.99mTcN核标记的新型心肌灌注显像剂的研究[J].高等学校化学学报,2006,27(6):1016-1019. |
| 作者姓名： | 楚进锋 孔德靖 李彬 王学斌 陆洁 王金城 米宏志 赵建冬 |
| 作者单位： | 1. 北京化工大学理学院,北京,100029 2. 北京师范大学化学系,北京,100875 3. 北京安贞医院核医学科,北京100029 |
| 摘 要： | 通过配体交换反应制备了99mTcN(PNP5)(DEDC)]+和99mTcN(PNP5)(DPODC)]+两种新配合物, 其放化纯度均大于90%. 生物性能研究结果表明: 两种配合物在小鼠心肌中的初始摄取高, 肝、肺等非靶组织清除快, 靶/非靶比高, 有利于早期心肌显像. 其中, 99mTcN(PNP5)(DEDC)]+在小鼠中的性质较优, 且其在狗体内的性质接近99mTc-tetrofosmin, 有望成为一种新型心肌灌注显像剂. |
| 关 键 词： | 99mTcN核 心肌灌注显像剂 生物分布 |
| 文章编号： | 0251-0790（2006）06-1016-04 |
| 收稿时间： | 05 8 2005 12:00AM |
| 修稿时间： | 2005-05-08 |
Novel 99mTc-nitride Heterocomplexes as Potential Myocardial Perfusion Imaging Agents |
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| CHU Jin-Feng,KONG De-Jing,LI Bin,WANG Xue-Bin,LU Jie,WANG Jin-Cheng,MI Hong-Zhi,ZHAO Jian-Dong.Novel 99mTc-nitride Heterocomplexes as Potential Myocardial Perfusion Imaging Agents[J].Chemical Research In Chinese Universities,2006,27(6):1016-1019. | |
| Authors: | CHU Jin-Feng KONG De-Jing LI Bin WANG Xue-Bin LU Jie WANG Jin-Cheng MI Hong-Zhi ZHAO Jian-Dong |
| Institution: | 1. College of Science, Beijing University of Chemical Technology, Beijing 100029, China; 2. Department of Chemistry, Beijing Normal University, Beijing 100875, China; 3. Department of Nuclear Medicine, Beijing Anzhen Hospital, Beijing 100029, China |
| Abstract: | To develop a new potential myocardial imaging agent,()~(99m)TcN(PNP5)(DEDC)]~(+) and(()()~(99m)TcN(PNP5)(DPODC)]~(+)) were prepared through ligand exchange reaction.Their radiochemical purities were over 90%.The results of biodistribution in mice indicate that they possessed a high myocardial uptake,rapid clearance from non-target tissues and good ratios of target to non-target.And ()~(99m)TcN(PNP5)\5(DEDC)]~(+) is superior.SPECT imaging in dog shows that its properties were similar to those of()()~(99m)Tc-(tetrofosmin).Based on its promising characters,it may be suitable for myocardial perfusion imaging. |
| Keywords: | Technetium-99m-nitride core Myocardial perfusion imaging agent Biodistribution |
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