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Synthesis,Bioactivity and Crystal Structure Analysis of 2-(Benzo[d]isothiazol-3-yloxy)-N-(3-cyano-1-(4-fluorophenyl)-1H-pyrazol-5-yl) Acetamide |
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| Authors: | YU Peng LI Xi HU Jun XU Yan-Hua |
| Affiliation: | 1. College of Biotechnology and Pharmaceutical Engineering,Nanjing University of Technology, Nanjing 210009, China;Jiangsu Key Laboratory of Industrial Water-conservation & Emission Reduction, Nanjing 210009, China 2. College of Environment, Nanjing University of Technology, Nanjing 210009, China;Jiangsu Key Laboratory of Industrial Water-conservation & Emission Reduction, Nanjing 210009, China 3. Post-doctoral Research Station of Chemical Engineering and Technology,Nanjing University of Technology, Nanjing 210009, China |
| Abstract: | A novel benzisothiazolin-3-one derivative, 2-(benzo[d]isothiazol-3-yloxy)-N-(3-cyano-1-(4-fluorophenyl)-1H-pyrazol-5-yl) acetamide(8), was synthesized from the initial compound benzo[d]isothiazol-3(2H)-one(BIT) 1 and 4-fluoroaniline 3. The structure of the target compound 8 was determined by elemental analyses, IR and 1H NMR. The single crystals of intermediate compound 6 and the target compound 8 were obtained and determined by X-ray diffraction analysis. The preliminary biological activity was also evaluated and the results showed the target compound exhibited a good anti-microbial activity. |
| Keywords: | benzisothiazol-(H)-one pyrazol synthesis bioactivity crystal structure |
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