Remote meta‐CH Olefination of Phenylacetic Acids Directed by a Versatile U‐Shaped Template |
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| Authors: | Dr Youqian Deng Prof?Dr Jin‐Quan Yu |
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| Institution: | Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) |
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| Abstract: | meta‐C? H olefination of phenylacetic acid derivatives has been achieved using a commercially available nitrile‐containing template. The identification of N‐formyl‐protected glycine as the ligand (Formyl‐Gly‐OH) was crucial for the development of this reaction. Versatility of the template approach in accommodating macrocyclopalladation processes with different ring sizes is demonstrated. |
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| Keywords: | C H activation olefination palladium phenylacetic acid template synthesis |
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