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Total Synthesis of (±)‐Hippolachnin A |
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| Authors: | Stefan A Ruider Tobias Sandmeier Prof?Dr Erick M Carreira |
| Institution: | Laboratorium für Organische Chemie, ETH Zürich, HCI H335, Vladimir‐Prelog‐Weg 3, 8093 Zürich (Switzerland) http://www.carreira.ethz.ch |
| Abstract: | The first total synthesis of the marine polyketide (±)‐hippolachnin A has been achieved in nine linear steps and an overall yield of 9 %. Rapid access to the oxacyclobutapentalene core structure was secured by strategic application of an ene cyclization. |
| Keywords: | ene reaction hippolachnin A natural products photochemistry total synthesis |