Asymmetric Dearomatization of β‐Naphthols through an Amination Reaction Catalyzed by a Chiral Phosphoric Acid |
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| Authors: | Shou‐Guo Wang Dr Qin Yin Dr Chun‐Xiang Zhuo Prof?Dr Shu‐Li You |
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| Institution: | 1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn/;2. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) |
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| Abstract: | A highly efficient catalytic asymmetric dearomatization of naphthols by means of an electrophilic amination reaction catalyzed by chiral phosphoric acid is presented. This protocol provides a facile access to functionalized β‐naphthalenone compounds with a chiral quaternary carbon center in excellent yields and enantioselectivity (up to 99 % yield, up to 96 % ee). |
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| Keywords: | amination reaction asymmetric catalysis dearomatization naphthol organocatalysis |
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