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Direct Asymmetric Dearomatization of 2‐Naphthols by Scandium‐Catalyzed Electrophilic Amination |
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| Authors: | Jiang Nan Prof. Dr. Jingjing Liu Huayu Zheng Zhijun Zuo Prof. Dr. Lei Hou Prof. Dr. Huaiming Hu Prof. Dr. Yaoyu Wang Prof. Dr. Xinjun Luan |
| Affiliation: | Key Laboratory of Synthetic and Natural Functional Molecular Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069 (China) |
| Abstract: | Catalytic asymmetric aminative dearomatization of 1‐substituted 2‐naphthols was successfully implemented with electrophilic azodicarboxylates under the catalysis of chiral ScIII/pybox complexes. This intermolecular reaction represents a hitherto unknown enantioselective C? N bond‐forming process through direct dearomatization of phenolic compounds to generate chiral nitrogen‐containing quaternary carbon stereocenters. |
| Keywords: | amination asymmetric catalysis dearomatization naphthol scandium |